Early efficacy signals in ovarian cancer patients in ongoing Ph1 trial: Poster reporting findings presented at SITC 2020 Annual Meeting

ENB Therapeutics reports preliminary data from the ongoing Phase 1/2 trial assessing the safety and efficacy of lead product ENB-003 in combination with pembrolizumab. Safety data are encouraging with no significant drug related safety events from the first 3 dosing cohorts. Best overall responses from the first 6 patients include 2 disease stabilizations and 1 confirmed partial response. The most encouraging responses were observed in 2 patients with platinum-resistant ovarian cancer who demonstrated 6% and 60% reduction in target lesions at the 150ug and 300ug doses respectively. The 150ug dose was sub therapeutic based upon weight and we anticipate enhanced efficacy as we continue to dose escalate. Download the poster by clicking the link below....

ENB Therapeutics Announces Successful Completion of the First Dosing Cohort in Phase 1 Clinical Trial of ENB-003 in Combination with Pembrolizumab

Monday, June 15, 2020 3:45 PMENB-003 is the Company’s first in class small molecule therapeutic selectively targeting the ETB receptor – a novel immune checkpoint NEW YORK, NY / ACCESSWIRE / June 15, 2020 / ENB Therapeutics, INC., a biotechnology company pioneering a new and differentiated class of therapeutics targeting the ETB receptor (ETBR), today announced the successful completion of the first dosing cohort in a Phase I dose escalation of ENB-003 in combination with pembrolizumab. The Phase I trial includes a monotherapy run-in followed by combination therapy. Doses of ENB-003 administered to date appear well-tolerated and the safety review committee has approved the dose escalation. ENB-003 is a selective and potent inhibitor of the ETBR receptor which is overexpressed in over 40% of all tumor types and blocks T-cell trafficking, thus creating “cold” tumors which have a high unmet need.“We are pleased that the doses of ENB-003 administered to date in combination with pembrolizumab appear to be very well tolerated and that our safety committee has approved moving on to the next higher dose,” said Sumayah Jamal, MD-PhD, President, Co-Founder and CSO of ENB Therapeutics, Inc. “We are very excited to have cleared this initial safety hurdle in the first clinical trial of a selective ETBR inhibitor (ETBRI) for cancer immunotherapy. ETBRIs have demonstrated preclinical proof of concept for overcoming anti-PD1 resistance across multiple cancer types. We believe that ENB-003, when combined with pembrolizumab in the anti-PD1 resistant patient population, may result in enhanced anti-tumor activity and immunologic effects.”The Phase I/II multi-center, open-label trial of ENB-003 is currently enrolling patients with advanced solid tumors in indications associated with ETBR expression....

IND approval received for lead product ENB-003

January 17, 2020 ENB Therapeutics receives IND approval from the FDA for our Phase 1/2 trial evaluating the safety and efficacy of lead product ENB-003 in combination with pembrolizumab. This is a major milestone for ENB and allows our clinical trial to be initiated as planned later this...

ENB to present at 2016 Pitch Fest organized by New York Bio

ENB was selected as one of 33 companies to present at this year’s Pitch Fest on May 11th, at the New York Bio Annual Conference. The conference is being held at NYC’s Time Warner Center. Representative entrepreneurs  will give a 15-minute pitch to a panel of judges made up of investors and other experts. This will be followed by 5 minutes of Q&A and 5 minutes of non-rebuttal feedback from the panel. Pitches will be evaluated and scored on a range of important business and scientific criteria. Leading scorers and winners will be announced during the keynote program later in the day. Judges for this year’s pitch fest hail from Merck, Sanofi, Pfizer, J&J, Lilly, leading VC law and accounting, and many...

ENB CSO and Co-founder Dr. Sumayah Jamal wins Best-in-show at 1st Pitch Life Science NYC

April, 2016 1st Pitch Life Science is organized by MABA (Mid Atlantic Bio Angels (www.bioangels.net), a life science investor group, to encourage and educate aspiring life science entrepreneurs who want the opportunity to practice their pitch and to receive constructive criticism from experienced and knowledgeable professionals. ENB’s investor presentation was one of 3 chosen for the event. ENB’s CSO Dr. Sumayah Jamal gave the presentation and was voted by an audience of over 100 as “Best-in-Show”. ENB is now qualified to advance to the  annual “Best of the Best/People’s Choice”...

ENB Therapeutics accepted for presentation at the 2016 HemOnc Today Melanoma Conference in NYC

March, 2016 ENB Therapeutics presents poster entitled “Development of ENB-001 for the Treatment of Melanoma Brain Metastasis” at the 2016 HemOnc Today Melanoma and Cutaneous Malignancies Meeting in NYC. The meeting draws more than 250 colleagues and renowned speakers with a program designed for oncologists, dermatologists, researchers and students. The poster abstract is below: As systemic therapy improves, patients with melanoma are living longer. As a result, 44% – 76% of all those diagnosed with advanced melanoma are developing, and dying from, melanoma that metastasizes to the central nervous system (CNS), specifically the brain. This catastrophic event is the most common cause of death in patients with melanoma and there are no approved therapies specifically for melanoma with CNS involvement. A common cause of resistance to melanoma treatment is upregulation of the endothelin B receptor (ETBR). ENB-001 is a small molecule that precisely targets the ETBR, inhibiting downstream RAF, MEK and AKT activity. ENB-001 has achieved proof of concept in animal models of CNS melanoma as well as extra-CNS melanoma metastases. Efficacy in preclinical studies for glioblastoma and squamous cell carcinoma has also been demonstrated. ENB-001, in contrast to approved MEK inhibitors, also has immunostimulatory effects, enhancing T-cell homing and adhesion to cancer cell vasculature. We have partnered with a drug formulation company that has a proprietary nanoparticle intranasal delivery system that bypasses the blood brain barrier, and will be used to deliver ENB-001 directly to the central nervous system. The development of ENB-001 will have a significant impact for patients with CNS melanoma. Further opportunities include the treatment of non-CNS melanoma metastatic disease, other malignancies, and the development of...